Automated CGE-LIF Nucleic Acid Analyzer (400 Advance)
Benchtop capillary electrophoresis system with LED-induced fluorescence detection — RNA/DNA fragment size, concentration and integrity from 1 µL of sample, in minutes.
Ships with certificate of analysis
For Research Use OnlyOverview
The system
The 400 Advance is a benchtop automated capillary gel electrophoresis (CGE-LIF) platform for nucleic acid quality control. It separates fragments by size in a capillary filled with replaceable polymer and detects them via four-channel LED-induced fluorescence — delivering size, concentration and integrity data with digital gel images, with no manual gel preparation.
For LNP and mRNA workflows it answers the payload QC questions: RNA integrity before encapsulation, fragment distribution, purity and residual free RNA — from as little as 1 µL of sample.
Key specifications
| Detection | Fluorescence, 4 channels |
|---|---|
| Light source | LED |
| Separation voltage | 1–15 kV |
| Sample throughput | 1–100 samples per run |
| Analysis speed | 1–7 min per 4 samples (< 1 kb) |
| Resolution | 1–4 bp (< 500 bp) |
| Sensitivity | 1 pg/µL |
| Sample consumption | ≤ 1 µL |
| Vial formats | 1 µL Micro Vial · 10 µL (0.1 mL tube) · 20 µL (0.2 mL tube) |
| Power | AC 110–240 V, 60 W |
| Connectivity | USB, built-in computer |
| Dimensions / weight | 54 × 40 × 36 cm / 26 kg |
| Software | Q-Analyzer (qualitative & quantitative analysis, gel image, report export) |
Cartridge compatibility
The system runs pre-filled single-use cartridges — no gel casting, no buffer prep:
| DNA cartridges | S1 · S2 · S3 · F3 · N1 · N3 |
|---|---|
| RNA cartridges | R1 · NR1 |
| Protein cartridge | P2 |
| Capacity per cartridge | 400–1,200 samples |
Each cartridge ships with running buffer, mineral oil, tubes and marker — see the CE Cartridge Kits page for the consumable line.
Applications
mRNA integrity and fragment analysis for LNP payload QC; siRNA and gRNA quality control; plasmid and IVT reaction analysis; NGS library QC.
| Product | Automated CGE-LIF Nucleic Acid Analyzer (400 Advance) |
|---|---|
| Category | QC & Analysis |
| Documentation | Certificate of analysis provided with every lot |
| Intended use | For Research Use Only (RUO). Not for diagnostic or therapeutic use. |
Related products
RNA-LNP Encapsulation Efficiency Assay Kit (RiboGreen-based)
Plate-based fluorescence assay for RNA encapsulation efficiency in LNP formulations — total vs. free RNA in 30–60 minutes on any standard fluorescence microplate reader.
CE Cartridge Kits (S1 / R1 Series)
Ready-to-use single-use cartridges for the 400 Advance CGE-LIF system — 800 runs per cartridge, 10–50,000 bp, no gel preparation.
Gel Retardation Assay Bundle
Complete consumable bundle for agarose gel retardation screening of LNP encapsulation — the fastest low-cost check that RNA is packed.
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